• Age above or equal to 45 years
• Have a BMI >27.0 kg/m2
• Participants have established atherosclerotic cardiovascular disease ASCVD and/or chronic kidney disease CKD as evidenced at least one of the following:
  • Coronary artery disease
  • Cerebrovascular disease
  • Peripheral arterial disease
  • Chronic kidney disease
• Does not have acute decompensated heart failure requiring hospitalization.
• Does not have ave New York Heart Association (NYHA) Classification Class IV heart failure
• Kidney related:
  • Participant does not have an eGFR <20 mL/min/1.73 m^2
  • Does not have UACR >5000 mg/g 
  • Does not have received any form of dialysis within 90 days
  • Does not have either undergone a kidney transplant or have a transplant procedure scheduled
• Other medical conditions:
  • Participants have not had or do not plan to have a surgical treatment for obesity.
  • Do not ahve a history of chronic or acute pancreatitis
  • Do not have a family or personal history of medullary thyroid carcinoma or multiple endocrine neoplasia (MEN) syndrome type 2
  • Do not have a known clinically significant gastric emptying abnormality, such as severe gastroparesis or gastric outlet obstruction

• There will be about 34 study visits, 19 office and 15 phone visits over about five years.
• Patients may be compensated for each completed visit.
• Patients will receive lab tests, diabetes medications, physical exams, and study related care at no cost.
• Patients will be directed to their own doctor for normal care/non-study related health concerns.

• Age above or equal to 18
• Have Lipoprotein(a) [Lp(a)] ≥175 nanomoles per liter (nmol/L).
• Meet criteria of either 2a or 2b:

2a: Individuals 18 years of age or older with established atherosclerotic cardiovascular disease (ASCVD) with an event or revascularization.

2b: Individuals 55 years of age or older who are at risk for a first cardiovascular (CV) event and either: Documented coronary artery disease (CAD), carotid stenosis, or peripheral artery disease (PAD) without history of event or revascularization; known familial hypercholesteremia; or a combination of high-risk factors.

• Have not had a major cardiovascular event or surgery, such as myocardial infarction (MI), stroke or coronary or peripheral revascularization, < 90 days before screening.
• Do not have uncontrolled hypertension
• Does not have New York Heart Association class IV heart failure.
• Does not have acute or chronic hepatitis, signs and symptoms of any other liver disease other than nonalcoholic fatty liver disease, or any of these laboratory results as determined by the central laboratory at screening.

• There will be about 25 study visits, 18 office and 7 phone visits over about four years
• Patients may be compensated up to $1,428.00.00 if all visits are completed.
• Patients will receive lab tests, diabetes medications, physical exams, and study related care at no cost.
• Patients will be directed to their own doctor for normal care/non-study related health concerns.

• Male or female over the age of 18
• Diagnosis of Parkinson’s disease
• Has Internet access to provide data online

For more information please visit:  www.foxinsight.org/clinic

• Surveys on health-related topics to be completed every 3 months for 5 years
• Optional, one-time surveys and sub-studies including genetic testing and counseling at no cost
• Appointment reminders and physician reports online for patients